Arsenic and urinary bladder cell proliferation.

  title={Arsenic and urinary bladder cell proliferation.},
  author={Michael I. Luster and Petia Simeonova},
  journal={Toxicology and applied pharmacology},
  volume={198 3},
Epidemiologic studies have demonstrated that a close association exists between the elevated levels of arsenic in drinking water and the incidence of certain cancers, including transitional cell carcinomas of the urinary bladder. We have employed in vitro and in vivo models to examine the effects of sodium arsenite on the urinary bladder epithelium. Mice exposed to 0.01% sodium arsenite in drinking water demonstrated hyperproliferation of the bladder uroepithelium within 4 weeks after… CONTINUE READING


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