Arsenic Trioxide inhibits the growth of human ovarian carcinoma cell line.

@article{Bornstein2005ArsenicTI,
  title={Arsenic Trioxide inhibits the growth of human ovarian carcinoma cell line.},
  author={Jacob Bornstein and S Bhaskara Ramaraju Sagi and Amer Haj and Jeffrey Harroch and Fuad Fares},
  journal={Gynecologic oncology},
  year={2005},
  volume={99 3},
  pages={726-9}
}
OBJECTIVE To determine whether Arsenic Trioxide may be an effective treatment of human ovarian carcinoma, we examined if it induced apoptosis in human ovarian cancer cell line. METHODS The human ovarian cell line SKOV3 was exposed to different concentrations of As2O3: 0 (control), 0.1 microM, 1 microM, 5 microM and 10 microM. The effect on cells proliferation and apoptotic parameters was examined. RESULTS The most effective inhibitory Arsenic Trioxide concentrations were 5 microM and 10… CONTINUE READING