Arsenic Trioxide Impacts Viral Latency and Delays Viral Rebound after Termination of ART in Chronically SIV‐Infected Macaques

@article{Yang2019ArsenicTI,
  title={Arsenic Trioxide Impacts Viral Latency and Delays Viral Rebound after Termination of ART in Chronically SIV‐Infected Macaques},
  author={Qing Yang and F. Feng and Pingchao Li and Enxiang Pan and Chunxiu Wu and Y. He and Fan Zhang and J. Zhao and Ruiting Li and L. Feng and F. Hu and Linghua Li and H. Zou and W. Cai and T. Lehner and Caijun Sun and L. Chen},
  journal={Advanced Science},
  year={2019},
  volume={6}
}
  • Qing Yang, F. Feng, +14 authors L. Chen
  • Published 2019
  • Medicine
  • Advanced Science
  • Abstract The latent viral reservoir is the source of viral rebound after interruption of antiretroviral therapy (ART) and is the major obstacle in eradicating the latent human immunodeficiency virus‐1 (HIV‐1). In this study, arsenic class of mineral, arsenic trioxide, clinically approved for treating acute promyelocytic leukemia, is demonstrated to reactivate latent provirus in CD4+ T cells from HIV‐1 patients and Simian immunodeficiency virus (SIV)‐infected macaques, without significant… CONTINUE READING
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