Arsenic Exposure and Type 2 Diabetes: A Systematic Review of the Experimental and Epidemiologic Evidence

@inproceedings{NavasAcin2006ArsenicEA,
  title={Arsenic Exposure and Type 2 Diabetes: A Systematic Review of the Experimental and Epidemiologic Evidence},
  author={Ana Navas-Aci{\'e}n and Ellen Kovner Silbergeld and Robin A. Streeter and Jeanne M Clark and Thomas Burke and Eliseo Guallar},
  booktitle={Environmental health perspectives},
  year={2006}
}
Chronic arsenic exposure has been suggested to contribute to diabetes development. We performed a systematic review of the experimental and epidemiologic evidence on the association of arsenic and type 2 diabetes. We identified 19 in vitro studies of arsenic and glucose metabolism. Five studies reported that arsenic interfered with transcription factors involved in insulin-related gene expression: upstream factor 1 in pancreatic beta-cells and peroxisome proliferative-activated receptor gamma… CONTINUE READING