Arsenic/interferon specifically reverses 2 distinct gene networks critical for the survival of HTLV-1-infected leukemic cells.

@article{Nasr2003ArsenicinterferonSR,
  title={Arsenic/interferon specifically reverses 2 distinct gene networks critical for the survival of HTLV-1-infected leukemic cells.},
  author={Rihab R. Nasr and Andreas Rosenwald and Marwan Eid El-Sabban and Bertrand Arnulf and Pierre A. Zalloua and Yves Lepelletier and Françoise Bex and Olivier Hermine and Louis Staudt and Hugues de Th{\'e} and Ali Bazarbachi},
  journal={Blood},
  year={2003},
  volume={101 11},
  pages={4576-82}
}
Adult T-cell leukemia (ATL) is a severe chemotherapy-resistant malignancy associated with prolonged infection by the human T cell-lymphotropic virus 1 (HTLV-1) retrovirus. Although the Tax viral transactivator is clearly an oncogene, the role of its continuous expression in the maintenance of the transformed phenotype is controversial. Because arsenic trioxide (As) and interferon alpha (IFN) synergize to induce cell cycle arrest and apoptosis of ATL cells both ex vivo and in vitro, we… CONTINUE READING

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