Arsenic(III) species inhibit oxidative protein folding in vitro.

  title={Arsenic(III) species inhibit oxidative protein folding in vitro.},
  author={Danny Ramadan and Pumtiwitt C Rancy and Radhika P Nagarkar and Joel P Schneider and Colin Thorpe},
  volume={48 2},
The success of arsenic trioxide in the treatment of acute promyelocytic leukemia has renewed interest in the cellular targets of As(III) species. The effects of arsenicals are usually attributed to their ability to bind vicinal thiols or thiol selenols in prefolded proteins thereby compromising cellular function. The present studies suggest an additional, more pleiotropic, contribution to the biological effects of arsenicals. As(III) species, by avid coordination to the cysteine residues of… CONTINUE READING
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