Arsenate reductase from S. aureus plasmid pI258 is a phosphatase drafted for redox duty

@article{Zegers2001ArsenateRF,
  title={Arsenate reductase from S. aureus plasmid pI258 is a phosphatase drafted for redox duty},
  author={Ingrid Zegers and Jos{\'e} Carlos Martins and Rudolph Willem and Lode Wyns and Joris Messens},
  journal={Nature Structural Biology},
  year={2001},
  volume={8},
  pages={843-847}
}
Arsenate reductase (ArsC) from Staphylococcus aureus plasmid pI258 plays a role in bacterial heavy metal resistance and catalyzes the reduction of arsenate to arsenite. The structures of the oxidized and reduced forms of ArsC were solved. ArsC has the PTPase I fold typical for low molecular weight tyrosine phosphatases (LMW PTPases). Remarkably, kinetic experiments show that pI258 ArsC also catalyzes the tyrosine phosphatase reaction in addition to arsenate reduction. These results provide… CONTINUE READING

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