Arsenate perturbation of human keratinocyte differentiation.

  title={Arsenate perturbation of human keratinocyte differentiation.},
  author={D J Kachinskas and Marjorie A. Phillips and Qin Qin and Joanna D Stokes and Robert H. Rice},
  journal={Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research},
  volume={5 11},
Treatment of cultured malignant human keratinocytes with sodium arsenate greatly suppressed expression of involucrin, a specific marker of keratinocyte differentiation. This action was primarily attributable to inhibition of involucrin transcription according to message run-on and stability measurements. Involucrin was suppressed in nontumorigenic keratinocytes as well, although the efficacy of suppression was less dramatic in cells derived from clinically normal epidermis. Several transition… CONTINUE READING


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