Arsenate-Induced Neural Tube Defects Not Influenced by Constant Rate Administration of Folic Acid

@article{Ferm1986ArsenateInducedNT,
  title={Arsenate-Induced Neural Tube Defects Not Influenced by Constant Rate Administration of Folic Acid},
  author={Vergil H Ferm and David P Hanlon},
  journal={Pediatric Research},
  year={1986},
  volume={20},
  pages={761-762}
}
ABSTRACT. Serious suggestions have been made that dietary supplementation with folic acid (FA) and perhaps other vitamins during pregnancy may reduce the incidence of neural tube defect (NTD) in human newborns. The purpose of these experiments was to evaluate the effect of continuous infusion of FA on the incidence of NTDs induced by arsenate. This teratogen induces NTDs in up to 90% of golden hamster fetuses when administered acutely during critical stages of embryogenesis. FA was administered… CONTINUE READING