Ars2 Links the Nuclear Cap-Binding Complex to RNA Interference and Cell Proliferation


Here we identify a component of the nuclear RNA cap-binding complex (CBC), Ars2, that is important for miRNA biogenesis and critical for cell proliferation. Unlike other components of the CBC, Ars2 expression is linked to the proliferative state of the cell. Deletion of Ars2 is developmentally lethal, and deletion in adult mice led to bone marrow failure… (More)
DOI: 10.1016/j.cell.2009.04.046


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