Arrhythmogenic remodeling of β2 versus β1 adrenergic signaling in the human failing heart.

Abstract

BACKGROUND Arrhythmia is the major cause of death in patients with heart failure, for which β-adrenergic receptor blockers are a mainstay therapy. But the role of β-adrenergic signaling in electrophysiology and arrhythmias has never been studied in human ventricles. METHODS AND RESULTS We used optical imaging of action potentials and [Ca(2+)]i transients… (More)
DOI: 10.1161/CIRCEP.114.002065

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@article{Lang2015ArrhythmogenicRO, title={Arrhythmogenic remodeling of β2 versus β1 adrenergic signaling in the human failing heart.}, author={Di Lang and Katherine M. Holzem and Chaoyi Kang and Mengqian Xiao and Hye Jin Hwang and Gregory A. Ewald and K. Yamada and Igor R. Efimov}, journal={Circulation. Arrhythmia and electrophysiology}, year={2015}, volume={8 2}, pages={409-19} }