Arrhythmogenic effects of beta2-adrenergic stimulation in the failing heart are attributable to enhanced sarcoplasmic reticulum Ca load.

@article{Desantiago2008ArrhythmogenicEO,
  title={Arrhythmogenic effects of beta2-adrenergic stimulation in the failing heart are attributable to enhanced sarcoplasmic reticulum Ca load.},
  author={Jaime Desantiago and Xun Ru Ai and Mohammed Shehadul Islam and Georgia Acuna and Mark T. Ziolo and Donald M. Bers and Steven M. Pogwizd},
  journal={Circulation research},
  year={2008},
  volume={102 11},
  pages={1389-97}
}
Ventricular tachycardia in heart failure (HF) can initiate by nonreentrant mechanisms such as delayed afterdepolarizations. In an arrhythmogenic rabbit model of HF, we have shown that isoproterenol induces ventricular tachycardia in vivo and aftercontractions and transient inward currents in HF myocytes. To determine whether beta(2)-adrenergic receptor (beta(2)-AR) stimulation contributes, we performed in vivo drug infusion, in vitro myocyte and biochemical studies. Intravenous zinterol (2.5… CONTINUE READING

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