Arrhythmogenic cardiomyopathy related DSG2 mutations affect desmosomal cadherin binding kinetics

@inproceedings{Dieding2017ArrhythmogenicCR,
  title={Arrhythmogenic cardiomyopathy related DSG2 mutations affect desmosomal cadherin binding kinetics},
  author={Mareike Dieding and Jana Davina Debus and Raimund Kerkhoff and Anna Gaertner-Rommel and Volker Walhorn and Hendrik Milting and Dario Anselmetti},
  booktitle={Scientific Reports},
  year={2017}
}
Cadherins are calcium dependent adhesion proteins that establish the intercellular mechanical contact by bridging the gap to adjacent cells. Desmoglein-2 (Dsg2) is a specific cadherin of the cell-cell contact in cardiac desmosomes. Mutations in the DSG2-gene are regarded to cause arrhythmogenic (right ventricular) cardiomyopathy (ARVC) which is a rare but severe heart muscle disease. The molecular pathomechanisms of the vast majority of DSG2 mutations, however, are unknown. Here, we… CONTINUE READING
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