Arrhythmogenic adverse effects of cardiac glycosides are mediated by redox modification of ryanodine receptors.

@article{Ho2011ArrhythmogenicAE,
  title={Arrhythmogenic adverse effects of cardiac glycosides are mediated by redox modification of ryanodine receptors.},
  author={Hsiang-Ting Ho and Sarah C. W. Stevens and Radmila Terentyeva and Cynthia A. Carnes and Dmitry Terentyev and S{\'a}ndor Gy{\"o}rke},
  journal={The Journal of physiology},
  year={2011},
  volume={589 Pt 19},
  pages={4697-708}
}
The therapeutic use of cardiac glycosides (CGs), agents commonly used in treating heart failure (HF), is limited by arrhythmic toxicity. The adverse effects of CGs have been attributed to excessive accumulation of intracellular Ca(2+) resulting from inhibition of Na(+)/K(+)-ATPase ion transport activity. However, CGs are also known to increase intracellular reactive oxygen species (ROS), which could contribute to arrhythmogenesis through redox modification of cardiac ryanodine receptors (RyR2s… CONTINUE READING
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