Arrhythmogenic Cardiomyopathy - New Insights into Disease Mechanisms and Drug Discovery.

@article{Asimaki2014ArrhythmogenicC,
  title={Arrhythmogenic Cardiomyopathy - New Insights into Disease Mechanisms and Drug Discovery.},
  author={Angeliki Asimaki and Andr{\'e} G. Kl{\'e}ber and Calum A. MacRae and Jeffrey E. Saffitz},
  journal={Progress in pediatric cardiology},
  year={2014},
  volume={37 1-2},
  pages={
          3-7
        }
}
Arrhythmogenic cardiomyopathy (ACM) is a primary myocardial disorder characterized by the early appearance of ventricular arrhythmias often out of proportion to the degree of ventricular remodeling and dysfunction. ACM typically presents in adolescence or early adulthood. It accounts for 10% of sudden cardiac deaths in individuals under the age of 18 years. Although there has been significant progress in recognizing the genetic determinants of ACM, how specific gene mutations cause the disease… CONTINUE READING
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