Arrhythmogenesis in experimental models of heart failure: the role of increased load.

OBJECTIVES To assess the effects of cardiac failure due to doxorubicin cardiotoxicity or chronic myocardial infarction on arrhythmia induction, ventricular repolarization and refractoriness in isolated perfused rabbit hearts under different loading conditions. METHODS Cardiac failure was induced by doxorubicin injection (1-1.25 mg.kg-1 twice weekly for 8… CONTINUE READING