Arrhythmogenesis by single ectopic beats originating in the Purkinje system.

  title={Arrhythmogenesis by single ectopic beats originating in the Purkinje system.},
  author={Makarand Deo and Patrick M. Boyle and Albert M. Kim and Edward J. Vigmond},
  journal={American journal of physiology. Heart and circulatory physiology},
  volume={299 4},
Cells in the Purkinje system (PS) are known to be more vulnerable than ventricular myocytes to secondary excitations during the action potential (AP) plateau or repolarization phases, known as early afterdepolarizations (EADs). Since myocytes have a lower intrinsic AP duration than the PS cells to which they are coupled, EADs occurring in distal branches of the PS are more likely to result in propagating ectopic beats. In this study, we use a computer model of the rabbit ventricles and PS to… CONTINUE READING


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