Arrhythmias and inhibition of noradrenaline uptake caused by tricyclic antidepressants and chlorpromazine on the isolated perfused rabbit heart
@article{Barth2004ArrhythmiasAI, title={Arrhythmias and inhibition of noradrenaline uptake caused by tricyclic antidepressants and chlorpromazine on the isolated perfused rabbit heart}, author={N. Barth and Markus Manns and Erich Muscholl}, journal={Naunyn-Schmiedeberg's Archives of Pharmacology}, year={2004}, volume={288}, pages={215-231} }
Summary1.Isolated rabbit hearts were perfused with a modified Tyrode solution containing noradrenaline in concentrations increasing stepwise from 5.9 nM to 5.9 μM at 5 min intervals. This dose regime was applied twice before and once 20 min after starting perfusion with one of 9 tricyclic drugs. Ventricular rate and right atrial and ventricular tensions were recorded using the transverse method.2.Infusions of noradrenaline evoked ventricular arrhythmias in hearts perfused with amitriptyline 4.8…
15 Citations
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