Arrhythmias and inhibition of noradrenaline uptake caused by tricyclic antidepressants and chlorpromazine on the isolated perfused rabbit heart

@article{Barth2004ArrhythmiasAI,
  title={Arrhythmias and inhibition of noradrenaline uptake caused by tricyclic antidepressants and chlorpromazine on the isolated perfused rabbit heart},
  author={N. Barth and Markus Manns and Erich Muscholl},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2004},
  volume={288},
  pages={215-231}
}
Summary1.Isolated rabbit hearts were perfused with a modified Tyrode solution containing noradrenaline in concentrations increasing stepwise from 5.9 nM to 5.9 μM at 5 min intervals. This dose regime was applied twice before and once 20 min after starting perfusion with one of 9 tricyclic drugs. Ventricular rate and right atrial and ventricular tensions were recorded using the transverse method.2.Infusions of noradrenaline evoked ventricular arrhythmias in hearts perfused with amitriptyline 4.8… 

The effect of tricyclic antidepressant drugs on the heart

The guinea-pig provides a good model for studying the arrhythmogenic actions of tricyclic antidepressants and doxepin was the most potent cardio-depressant in the spontaneously beating atrial preparation.

Effects of 5-hydroxytryptamine and related compounds on the sympathetic nerves of the rabbit heart

Findings confirm that the positive chronotropic effects of indolethylamines on the rabbit heart are due to noradrenaline release.

Effects of antidepressants on the intraventricular conduction and the incidence of arrhythmias induced by programmed ventricular stimulation in the dog heart after myocardial infarction

It can be expected that mianserin and adinazolam may have a much lower cardiac toxicity than amitriptyline, a standard tricyclic antidepressant.

THE EFFECT OF AMITRIPTYLINE ON PRESYNAPTIC MECHANISMS IN NORADRENERGIC NERVES

  • I. Hughes
  • Biology, Chemistry
    British journal of pharmacology
  • 1978
It is concluded that amitriptyline may raise synaptic levels of noradrenaline by blocking presynaptic α‐adrenoceptors controlling norADrenaline release and by blocking its uptake into sympathetic neurones.

PRESYNAPTIC cx-ADRENOCEPTOR BLOCKING PROPERTIES AMONG TRI-AND TETRACYCLIC ANTIDEPRESSANT DRUGS

It is concluded that mianserin and ORG GC 94 produce a blockade of presynaptic a-adrenoceptors which could contribute to an antidepressant effect but that this type of action is not common to all antidepressants.

The effects of several muscarinic antagonists on pre- and postsynaptic receptors in the isolated rabbit heart

It is concluded that the antagonists employed do not reveal differences between pre- and postsynaptic muscarine receptors of the rabbit heart, in spite of their greatly varying chemical structure and their individual affinities ranging over 5 orders of magnitude.

Inhibition of noradrenaline release from sympathetic nerves by pentobarbital

Pentobarbital concentrations of 10–100 μM selectively inhibited the noradrenaline release evoked by activation of the nicotinic receptors on the terminals sympathetic nerves of the rabbit heart.

Doxepin Up-to-Date: A Review of its Pharmacological Properties and Therapeutic Efficacy with Particular Reference to Depression

The more marked sedative properties of doxepin make it more useful than imipramine in depressed patients with sleep disturbances and in depression associated with anxiety, and it has an intrinsic cardiotoxicity on overdosage similar to other tricyclic antidepressants.

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