Arrhythmia/Electrophysiology Cardiomyocytes Derived From Pluripotent Stem Cells Recapitulate Electrophysiological Characteristics of an Overlap Syndrome of Cardiac Sodium Channel Disease

Abstract

Background—Pluripotent stem cells (PSCs) offer a new paradigm for modeling genetic cardiac diseases, but it is unclear whether mouse and human PSCs can truly model both gain-and loss-of-function genetic disorders affecting the Na ϩ current (I Na) because of the immaturity of the PSC-derived cardiomyocytes. To address this issue, we generated multiple PSC… (More)

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Cite this paper

@inproceedings{Davis2012ArrhythmiaElectrophysiologyCD, title={Arrhythmia/Electrophysiology Cardiomyocytes Derived From Pluripotent Stem Cells Recapitulate Electrophysiological Characteristics of an Overlap Syndrome of Cardiac Sodium Channel Disease}, author={Richard P Davis and Simona Casini and Cathelijne W. van den Berg and M. Hoekstra and Daniela C. F. Salvatori and Dorien Ward-van and Connie R. Bezzina and Arie O. Verkerk and Christine L Mummery}, year={2012} }