Arresting a Transient Receptor Potential (TRP) Channel

  title={Arresting a Transient Receptor Potential (TRP) Channel},
  author={Arun Kumar Shukla and Jihee Kim and Seungkirl Ahn and Kunhong Xiao and Sudha K Shenoy and Wolfgang B Liedtke and Robert J Lefkowitz},
  booktitle={The Journal of biological chemistry},
β-Arrestins, originally discovered to desensitize activated G protein-coupled receptors, (aka seven-transmembrane receptors, 7TMRs) also mediate 7TMR internalization and G protein-independent signaling via these receptors. More recently, several regulatory roles of β-arrestins for atypical 7TMRs and non-7TM receptors have emerged. Here, we uncover an entirely novel regulatory role of β-arrestins in cross-talk between the angiotensin receptor (AT1aR) and a member of the transient receptor… CONTINUE READING

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