Arrestin-mediated ERK activation by gonadotropin-releasing hormone receptors: receptor-specific activation mechanisms and compartmentalization.

@article{Caunt2006ArrestinmediatedEA,
  title={Arrestin-mediated ERK activation by gonadotropin-releasing hormone receptors: receptor-specific activation mechanisms and compartmentalization.},
  author={Christopher James Caunt and Ann R. Finch and Kathleen R Sedgley and Lisa Oakley and Louis M Luttrell and Craig Alexander McArdle},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 5},
  pages={2701-10}
}
Activation of seven-transmembrane region receptors typically causes their phosphorylation with consequent arrestin binding and desensitization. Arrestins also act as scaffolds, mediating signaling to Raf and ERK and, for some receptors, inhibiting nuclear translocation of ERK. GnRH receptors (GnRHRs) act via Gq/11 to stimulate the phospholipase C/Ca2+/protein kinase C (PKC) cascade and the Raf/MEK/ERK cassette. Uniquely, type I mammalian GnRHRs lack the C-tails that are found in other seven… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 20 extracted citations

TSH signalling and cancer.

Arquivos brasileiros de endocrinologia e metabologia • 2007
View 12 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…