Arrestin interactions with G protein-coupled receptors.

@article{Lohse2014ArrestinIW,
  title={Arrestin interactions with G protein-coupled receptors.},
  author={Martin J. Lohse and Carsten Hoffmann},
  journal={Handbook of experimental pharmacology},
  year={2014},
  volume={219},
  pages={15-56}
}
G-protein-coupled receptors (GPCRs) are the primary interaction partners for arrestins. The visual arrestins, arrestin1 and arrestin4, physiologically bind to only very few receptors, i.e., rhodopsin and the color opsins, respectively. In contrast, the ubiquitously expressed nonvisual variants β-arrestin1 and 2 bind to a large number of receptors in a fairly nonspecific manner. This binding requires two triggers, agonist activation and receptor phosphorylation by a G-protein-coupled receptor… CONTINUE READING
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β-Arrestin binding

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