Arrestin 3 mediates endocytosis of CCR7 following ligation of CCL19 but not CCL21.

@article{Byers2008Arrestin3M,
  title={Arrestin 3 mediates endocytosis of CCR7 following ligation of CCL19 but not CCL21.},
  author={Melissa A. Byers and Psachal A. Calloway and Laurie Shannon and Heather D. Cunningham and Sarah Smith and Fang Li and Brian C. Fassold and Charlotte M. Vines},
  journal={Journal of immunology},
  year={2008},
  volume={181 7},
  pages={4723-32}
}
Internalization of ligand bound G protein-coupled receptors, an important cellular function that mediates receptor desensitization, takes place via distinct pathways, which are often unique for each receptor. The C-C chemokine receptor (CCR7) G protein-coupled receptor is expressed on naive T cells, dendritic cells, and NK cells and has two endogenous ligands, CCL19 and CCL21. Following binding of CCL21, 21 +/- 4% of CCR7 is internalized in the HuT 78 human T cell lymphoma line, while 76 +/- 8… CONTINUE READING

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