Arrestin-3-Dependent Activation of c-Jun N-Terminal Kinases (JNKs).

Abstract

Only one out of four mammalian arrestin subtypes, arrestin-3, facilitates the activation of JNK family kinases. Here we describe two different protocols used for elucidating the mechanisms involved. One is based on reconstitution of signaling modules from purified proteins: arrestin-3, MKK4, MKK7, JNK1, JNK2, and JNK3. The main advantage of this method is… (More)
DOI: 10.1002/0471141755.ph0212s68

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