Arrested maturation of Neisseria-containing phagosomes in the absence of the lysosome-associated membrane proteins, LAMP-1 and LAMP-2.

@article{Binker2007ArrestedMO,
  title={Arrested maturation of Neisseria-containing phagosomes in the absence of the lysosome-associated membrane proteins, LAMP-1 and LAMP-2.},
  author={Marcelo Gustavo Binker and Laura Iris Cosen-Binker and Mauricio R Terebiznik and Gustavo Vidal Mallo and Shannon E. McCaw and E L Eskelinen and Marion Willenborg and John H Brumell and Paul Saftig and Sergio Grinstein and Scott D Gray-Owen},
  journal={Cellular microbiology},
  year={2007},
  volume={9 9},
  pages={2153-66}
}
Mature, microbicidal phagosomes are rich in the lysosome-associated membrane proteins, LAMP-1 and LAMP-2, two highly glycosylated proteins presumed to form a protective barrier lining the phagosomal membrane. Pathogenic Neisseria secrete a protease that selectively cleaves LAMP-1, suggesting a critical role for LAMP proteins in the microbicidal competence of phagosomes. To determine the requirement for LAMP proteins in bacterial phagocytosis, we employed embryonic fibroblasts isolated from… CONTINUE READING

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Mature , microbicidal phagosomes are rich in the lysosome - associated membrane proteins , LAMP-1 and LAMP-2 , two highly glycosylated proteins presumed to form a protective barrier lining the phagosomal membrane .
Mature , microbicidal phagosomes are rich in the lysosome - associated membrane proteins , LAMP-1 and LAMP-2 , two highly glycosylated proteins presumed to form a protective barrier lining the phagosomal membrane .
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