Arrest of spermatogenesis and defective breast development in mice lacking A-myb

@article{Toscani1997ArrestOS,
  title={Arrest of spermatogenesis and defective breast development in mice lacking A-myb},
  author={Antonio Toscani and Richard V. Mettus and Robert C Coupland and Henry Simpkins and Judith Litvin and Joanne M Orth and Kimi S. Hatton and E. P. Reddy},
  journal={Nature},
  year={1997},
  volume={386},
  pages={713-717}
}
The Myb gene family currently consists of three members, named A-, B- and c-myb1,2. These genes encode nuclear proteins that bind DNA in a sequence-specific manner and function as regulators of transcription. In adult male mice, A-myb is expressed predominantly in male germ cells2,3. In female mice, A-myb is expressed in breast ductal epithelium, mainly during pregnancy-induced ductal branching and alveolar development. We report here that mice homozygous for a germline mutation in A-myb… CONTINUE READING

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