Arrest of human mitochondrial RNA polymerase transcription by the biological aldehyde adduct of DNA, M1dG

Abstract

The biological aldehydes, malondialdehyde and base propenal, react with DNA to form a prevalent guanine adduct, M(1)dG. The exocyclic ring of M(1)dG opens to the acyclic N(2)-OPdG structure when paired with C but remains closed in single-stranded DNA or when mispaired with T. M(1)dG is a target of nucleotide excision repair (NER); however, NER is absent in… (More)
DOI: 10.1093/nar/gkq656

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@inproceedings{Cline2010ArrestOH, title={Arrest of human mitochondrial RNA polymerase transcription by the biological aldehyde adduct of DNA, M1dG}, author={Susan Cline and Maria Lodeiro and Lawrence J Marnett and Craig E Cameron and Jamie J Arnold}, booktitle={Nucleic acids research}, year={2010} }