Arrest defective 1 autoacetylation is a critical step in its ability to stimulate cancer cell proliferation.

@article{Seo2010ArrestD1,
  title={Arrest defective 1 autoacetylation is a critical step in its ability to stimulate cancer cell proliferation.},
  author={Ji Hae Seo and Jong-Ho Cha and Ji-Hyeon Park and Chul-Ho Jeong and Zee-Yong Park and Hye-suk Lee and Seung Hyun Oh and Ju-Hee Kang and Se Won Suh and Kyoung Hoon Kim and Jun Yong Ha and Sang Hee Han and Se-Hee Kim and Ji-Won Lee and Jeong Ae Park and J Jeong and Kong-Joo Lee and Goo Taeg Oh and Mi-Ni Lee and Sung Won Kwon and Seung-Ki Lee and Kwang-Hoon Chun and Su-Jae Lee and Kyu-Won Kim},
  journal={Cancer research},
  year={2010},
  volume={70 11},
  pages={4422-32}
}
The N-acetyltransferase arrest defective 1 (ARD1) is an important regulator of cell growth and differentiation that has emerged recently as a critical molecule in cancer progression. However, the regulation of the enzymatic and biological activities of human ARD1 (hARD1) in cancer is presently poorly understood. Here, we report that hARD1 undergoes autoacetylation and that this modification is essential for its functional activation. Using liquid chromatography-tandem mass spectrometry and site… CONTINUE READING
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Induction of apoptosis in human cells by RNAimediated knockdown of hARD1 and NATH, components of N-α-acetyltransferase. Oncogene 2006;25:4350–60

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