Arrest, adaptation, and recovery following a chromosome double-strand break in Saccharomyces cerevisiae.

@article{Lee2000ArrestAA,
  title={Arrest, adaptation, and recovery following a chromosome double-strand break in Saccharomyces cerevisiae.},
  author={Sang Eun Lee and Achille Pellicioli and Janos Demeter and Milind Vaze and Audrey P. Gasch and Anna Malkova and Patrick O. Brown and David Botstein and Tim Stearns and Marco Foiani and James E Haber},
  journal={Cold Spring Harbor symposia on quantitative biology},
  year={2000},
  volume={65},
  pages={303-14}
}
damage such as a double-strand break (DSB) of a chromosome causes eukaryotic cells to arrest cell cycle progression. Arrest provides a greater opportunity for cells to repair DNA damage prior to mitosis, which might cause cells to inherit chromosomes in which DNA repli-cation was not complete or in which broken chromosome segments, lacking a centromere, would be lost (Hartwell and Weinert 1989; Elledge 1996; Weinert 1998). DNA-damage-induced arrest is enforced by a network of checkpoint… CONTINUE READING

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