Array-based comparative genomic hybridization reveals recurrent chromosomal aberrations and Jab1 as a potential target for 8q gain in hepatocellular carcinoma.

@article{Patil2005ArraybasedCG,
  title={Array-based comparative genomic hybridization reveals recurrent chromosomal aberrations and Jab1 as a potential target for 8q gain in hepatocellular carcinoma.},
  author={Mohini A Patil and Ines Guetgemann and Ji Zhang and Coral Ho and S K Cheung and David Ginzinger and Rui Li and Karl J. Dykema and Samuel So and Sheung-tat Fan and Sanjay Kakar and Kyle A. Furge and Reinhard Buettner and Xin Jane Chen},
  journal={Carcinogenesis},
  year={2005},
  volume={26 12},
  pages={2050-7}
}
Hepatocellular carcinoma (HCC) is one of the major malignancies worldwide. We have previously characterized global gene expression patterns in HCC using microarrays. Here, we report the analysis of genomic DNA copy number among 49 HCC samples using BAC array-based comparative genomic hybridization (CGH). We observed recurrent and characteristic chromosomal aberrations, including frequent DNA copy number gains of 1q, 6p, 8q and 20q, and losses of 4q, 8p, 13q, 16q and 17p. We correlated gene… CONTINUE READING