Array-based assay detects genome-wide 5-mC and 5-hmC in the brains of humans, non-human primates, and mice

@inproceedings{Chopra2013ArraybasedAD,
  title={Array-based assay detects genome-wide 5-mC and 5-hmC in the brains of humans, non-human primates, and mice},
  author={Pankaj Chopra and Ligia Assumpç{\~a}o Papale and Andrew T J White and Andrea L Hatch and Ryan M Brown and Mark A. Garthwaite and Patrick H. Roseboom and Thaddeus G Golos and Stephen T Warren and Reid S Alisch},
  booktitle={BMC Genomics},
  year={2013}
}
Methylation on the fifth position of cytosine (5-mC) is an essential epigenetic mark that is linked to both normal neurodevelopment and neurological diseases. The recent identification of another modified form of cytosine, 5-hydroxymethylcytosine (5-hmC), in both stem cells and post-mitotic neurons, raises new questions as to the role of this base in mediating epigenetic effects. Genomic studies of these marks using model systems are limited, particularly with array-based tools, because the… CONTINUE READING
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