Array Comparative Genomic Hybridization Analysis of Colorectal Cancer Cell Lines and Primary Carcinomas

  title={Array Comparative Genomic Hybridization Analysis of Colorectal Cancer Cell Lines and Primary Carcinomas},
  author={Eleanor J Douglas and Heike Fiegler and Andrew J. Rowan and Sarah Halford and David C. Bicknell and Walter F. Bodmer and Ian P. M. Tomlinson and Nigel P. Carter},
  journal={Cancer Research},
  pages={4817 - 4825}
Array comparative genomic hybridization, with a genome-wide resolution of ∼1 Mb, has been used to investigate copy number changes in 48 colorectal cancer (CRC) cell lines and 37 primary CRCs. The samples were divided for analysis according to the type of genomic instability that they exhibit, microsatellite instability (MSI) or chromosomal instability (CIN). Consistent copy number changes were identified, including gain of chromosomes 20, 13, and 8q and smaller regions of amplification such as… 

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