Arrangement of type IV collagen and laminin on substrates with controlled density of -OH groups.

  title={Arrangement of type IV collagen and laminin on substrates with controlled density of -OH groups.},
  author={Nuno Miranda Coelho and Cristina Gonz{\'a}lez-Garc{\'i}a and Manuel Salmer{\'o}n-S{\'a}nchez and George Altankov},
  journal={Tissue engineering. Part A},
  volume={17 17-18},
Collagen IV (Col IV) and laminin (Lam) are the main structural components of the basement membrane where they form two overlapping polymeric networks. We studied the adsorption pattern of these proteins on five model surfaces with tailored density of -OH groups obtained by copolymerization of different ratios ethyl acrylate (EA) and hydroxyl EA (HEA): X(OH)=0, X(OH)=0.3, X(OH)=0.5, X(OH)=0.7, and X(OH)=1 (where X refers the ratio of HEA). Atomic force microscopy revealed substratum-specific… CONTINUE READING


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