Arrangement of human immunoglobulin heavy chain constant region genes implies evolutionary duplication of a segment containing γ, ε and α genes

@article{Flanagan1982ArrangementOH,
  title={Arrangement of human immunoglobulin heavy chain constant region genes implies evolutionary duplication of a segment containing γ, ε and α genes},
  author={John G. Flanagan and Terence H Rabbitts},
  journal={Nature},
  year={1982},
  volume={300},
  pages={709-713}
}
Cosmid clones containing the human γ, ε and α heavy chain constant region genes and an ε pseudogene have been isolated. All these genes have a switch sequence detectable by hybridization. We have studied overlapping cosmids covering two separate regions of the genome, and the gene order in each of these regions was found to be γ–γ–ε–α. This implies an evolutionary duplication in this multigene family involving γ, ε and α genes. 

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