Arp2/3 controls the motile behavior of N-WASP-functionalized GUVs and modulates N-WASP surface distribution by mediating transient links with actin filaments.

@article{Delatour2008Arp23CT,
  title={Arp2/3 controls the motile behavior of N-WASP-functionalized GUVs and modulates N-WASP surface distribution by mediating transient links with actin filaments.},
  author={Vincent Delatour and Emmanu{\`e}le Helfer and Dominique Didry and Kim H{\^o} Di{\^e}p L{\^e} and Jean-François Gaucher and M. Carlier and Guillaume Romet-Lemonne},
  journal={Biophysical journal},
  year={2008},
  volume={94 12},
  pages={4890-905}
}
Spatially controlled assembly of actin in branched filaments generates cell protrusions or the propulsion of intracellular vesicles and pathogens. The propulsive movement of giant unilamellar vesicles (GUVs) functionalized by N-WASP (full-length or truncated) is reconstituted in a biochemically controlled medium, and analyzed using phase contrast and fluorescence microscopy to elucidate the links between membrane components and the actin cytoskeleton that determine motile behavior. Actin-based… CONTINUE READING
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