Arp2/3 complex is essential for actin network treadmilling as well as for targeting of capping protein and cofilin

@inproceedings{Koestler2013Arp23CI,
  title={Arp2/3 complex is essential for actin network treadmilling as well as for targeting of capping protein and cofilin},
  author={Stefan A. Koestler and Anika Steffen and Maria Nemethova and Moritz Winterhoff and Ningning Luo and J. Margit Holleboom and Jessica Krupp and Sonja Jacob and Marlene Vinzenz and Florian Schur and Kai Schl{\"u}ter and Peter W Gunning and Christoph Winkler and Christian Schmeiser and Jan Faix and Theresia Stradal and J. Victor Small and Klemens Rottner},
  booktitle={Molecular biology of the cell},
  year={2013}
}
Lamellipodia are sheet-like protrusions formed during migration or phagocytosis and comprise a network of actin filaments. Filament formation in this network is initiated by nucleation/branching through the actin-related protein 2/3 (Arp2/3) complex downstream of its activator, suppressor of cAMP receptor/WASP-family verprolin homologous (Scar/WAVE), but the relative relevance of Arp2/3-mediated branching versus actin filament elongation is unknown. Here we use instantaneous interference with… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 93 REFERENCES

Direct Determination of Actin Polarity in the Cell

VIEW 4 EXCERPTS

The Arp2/3 complex is required for lamellipodia extension and directional fibroblast cell migration

VIEW 9 EXCERPTS
HIGHLY INFLUENTIAL

Characterization of two classes of small molecule inhibitors of Arp2/3 complex

VIEW 10 EXCERPTS
HIGHLY INFLUENTIAL

Tissue-specific Tropomyosin Isoform Composition

VIEW 4 EXCERPTS