Arp2/3 Complex and Cofilin Modulate Binding of Tropomyosin to Branched Actin Networks

@article{Hsiao2015Arp23CA,
  title={Arp2/3 Complex and Cofilin Modulate Binding of Tropomyosin to Branched Actin Networks},
  author={Jennifer Ying Hsiao and Lauren M. Goins and Natalie A. Petek and R. Dyche Mullins},
  journal={Current Biology},
  year={2015},
  volume={25},
  pages={1573-1582}
}
Tropomyosins are coiled-coil proteins that bind actin filaments and regulate multiple cytoskeletal functions, including actin network dynamics near the leading edge of motile cells. Previous work demonstrated that tropomyosins inhibit actin nucleation by the Arp2/3 complex and prevent filament disassembly by cofilin. We find that the Arp2/3 complex and cofilin, in turn, regulate the binding of tropomyosin to actin filaments. Using fluorescence microscopy, we show that tropomyosin (non-muscle… CONTINUE READING
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