Arousal dissociates amygdala and hippocampal fear responses: evidence from simultaneous fMRI and skin conductance recording.

@article{Williams2001ArousalDA,
  title={Arousal dissociates amygdala and hippocampal fear responses: evidence from simultaneous fMRI and skin conductance recording.},
  author={Leanne M. Williams and Mary L. Phillips and Michael J. Brammer and David Skerrett and Jim Lagopoulos and Chris Rennie and Homayoun Bahramali and Gloria Olivieri and A. S. David and Anthony Peduto and Evian Gordon},
  journal={NeuroImage},
  year={2001},
  volume={14 5},
  pages={1070-9}
}
The experience and appraisal of threat is essential to human and animal survival. Lesion evidence suggests that the subjective experience of fear relies upon amygdala-medial frontal activity (as well as autonomic arousal), whereas the factual context of threat stimuli depends upon hippocampal-lateral frontal activity. This amygdala-hippocampus dissociation has not previously been demonstrated in vivo. To explore this differentiation, we employed functional magnetic resonance imaging (fMRI) and… CONTINUE READING

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