Aromatic hydroxylation is a major metabolic pathway of the mycotoxin zearalenone in vitro.


Zearalenone (ZEN) is a common mycotoxin, for which only reductive metabolites have been identified so far. We now report that ZEN is extensively monohydroxylated by microsomes from human liver in vitro. Two of the major oxidative metabolites arise through aromatic hydroxylation and are catechols. Their chemical structures have been unambiguously determined… (More)
DOI: 10.1002/mnfr.200800584


Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.

Slides referencing similar topics