Aromatic hydroxylation is a major metabolic pathway of the mycotoxin zearalenone in vitro.

Abstract

Zearalenone (ZEN) is a common mycotoxin, for which only reductive metabolites have been identified so far. We now report that ZEN is extensively monohydroxylated by microsomes from human liver in vitro. Two of the major oxidative metabolites arise through aromatic hydroxylation and are catechols. Their chemical structures have been unambiguously determined… (More)
DOI: 10.1002/mnfr.200800584

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