Aromatic-dependent Salmonella typhimurium are non-virulent and effective as live vaccines

@article{Hoiseth1981AromaticdependentST,
  title={Aromatic-dependent Salmonella typhimurium are non-virulent and effective as live vaccines},
  author={Susan K. Hoiseth and Bruce A. D. Stocker},
  journal={Nature},
  year={1981},
  volume={291},
  pages={238-239}
}
An auxotrophic mutant which requires a metabolite not available in vertebrate tissues should be unable to grow in such tissue and thus be non-virulent. Most mutations to auxotrophy do not affect virulence1–3, presumably because the required metabolites are available at sufficient concentration. However, Bacon et al.1,2 noted that a Salmonella typhi mutant requiring p-amino-benzoic acid (p AB) was less virulent (for mice) than its parent. Salmonella, unlike vertebrates, cannot assimilate… CONTINUE READING
Highly Influential
This paper has highly influenced 77 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 717 extracted citations

Inhibition of Diverse DsbA Enzymes in Multi-DsbA Encoding Pathogens

Antioxidants & redox signaling • 2018
View 11 Excerpts
Highly Influenced

MTMR4 Is Required for the Stability of the Salmonella-Containing Vacuole

Front. Cell. Infect. Microbiol. • 2016
View 13 Excerpts
Highly Influenced

- 1-decoration of Outer Membrane Vesicles with Multiple 1 Antigens Using an Autotransporter Approach 2 3

Maria H Daleke-Schermerhorna, Tristan Felixc, +19 authors Joen Luirinka
2014
View 15 Excerpts
Highly Influenced

High-Resolution Single Nucleotide Polymorphism Analysis Distinguishes Recrudescence and Reinfection in Recurrent Invasive Nontyphoidal Salmonella Typhimurium Disease

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America • 2012
View 7 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…