Aromatic-dependent Salmonella typhimurium are non-virulent and effective as live vaccines

  title={Aromatic-dependent Salmonella typhimurium are non-virulent and effective as live vaccines},
  author={Susan K. Hoiseth and Bruce A. D. Stocker},
An auxotrophic mutant which requires a metabolite not available in vertebrate tissues should be unable to grow in such tissue and thus be non-virulent. Most mutations to auxotrophy do not affect virulence1–3, presumably because the required metabolites are available at sufficient concentration. However, Bacon et al.1,2 noted that a Salmonella typhi mutant requiring p-amino-benzoic acid (p AB) was less virulent (for mice) than its parent. Salmonella, unlike vertebrates, cannot assimilate… CONTINUE READING
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