Aromatic antiepileptic drugs and mitochondrial toxicity: effects on mitochondria isolated from rat liver.

@article{Santos2008AromaticAD,
  title={Aromatic antiepileptic drugs and mitochondrial toxicity: effects on mitochondria isolated from rat liver.},
  author={Neife Aparecida Guinaim dos Santos and Wanessa Silva Garcia Medina and N{\'a}dia Maria Martins and F{\'a}bio E Mingatto and Carlos Curti and Antonio Cardozo dos Santos},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  year={2008},
  volume={22 5},
  pages={1143-52}
}
Idiosyncratic hepatotoxicity is a well-known complication associated with aromatic antiepileptic drugs (AAED), and it has been suggested to occur due to the accumulation of toxic arene oxide metabolites. Although there is clear evidence of the participation of an immune process, a direct toxic effect involving mitochondria dysfunction is also possible. The effects of AAED on mitochondrial function have not been studied yet. Therefore, we investigated, in vitro, the cytotoxic mechanism of… CONTINUE READING

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