Aromatic amino-claisen rearrangement in the synthesis of ellipticine


A convenient route is described for the preparation of 1,4-dimethylcarbazole — the key compound in the synthesis of the antitumoral alkaloid ellipticine. The interaction of 2,5-xylidine with 3-chlorocyclohexene led to N-(cyclohex-2-enyl)-2,5-xylidine (I), the two-hour heating of which at 140–150°C gave the product of an amino-Claisen rearrangement, 6… (More)
DOI: 10.1007/BF00598268


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@article{Mustafin2004AromaticAR, title={Aromatic amino-claisen rearrangement in the synthesis of ellipticine}, author={Akhat G. Mustafin and Ilkhom Khalilov and I. B. Abdakhmanov and Genrikh A Tolstikov}, journal={Chemistry of Natural Compounds}, year={2004}, volume={25}, pages={693-695} }