Aromatic amino acid metabolism during liver failure.

  title={Aromatic amino acid metabolism during liver failure.},
  author={Cornelius H. C. Dejong and Marcel C. G. van de Poll and Peter B. Soeters and Rajiv Jalan and Steven W M Olde Damink},
  journal={The Journal of nutrition},
  volume={137 6 Suppl 1},
  pages={1579S-1585S; discussion 1597S-1598S}
Liver failure is associated with hepatic encephalopathy (HE). An imbalance in plasma levels of aromatic amino acids (AAA) phenylalanine, tyrosine, and tryptophan and branched chain amino acids (BCAA) and their BCAA/AAA ratio has been suggested to play a causal role in HE by enhanced brain AAA uptake and subsequently disturbed neurotransmission. Until recently, data on this subject and the role of the liver and splanchnic bed were scarce, particularly in humans, due to inaccessibility of portal… CONTINUE READING
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