Aromatase p450 expression in a feminizing adrenal adenoma presenting as isosexual precocious puberty.

@article{Phornphutkul2001AromatasePE,
  title={Aromatase p450 expression in a feminizing adrenal adenoma presenting as isosexual precocious puberty.},
  author={Chanika Phornphutkul and Tomoharu Okubo and K D Wu and Zeev Harel and Thomas F Tracy and Halit Pinar and Shiuan W Chen and Philip A Gruppuso and Gregory Goodwin},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2001},
  volume={86 2},
  pages={649-52}
}
A 7-yr-old girl presented with isosexual precocious puberty secondary to a feminizing adrenal adenoma. The adrenal tumor was found to express aromatase messenger ribonucleic acid. Enzyme kinetic studies revealed a high level of aromatase activity in the adrenal tumor, with a K(m) of 45 nmol/L and a maximum velocity of 25.6 pmol/mg.h. Aromatase activity was approximately 500-fold higher in the tumor than in adjacent normal adrenal tissue. Although histopathological examination of the tumor was… CONTINUE READING
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