Aromatase inhibitors in breast cancer.

  title={Aromatase inhibitors in breast cancer.},
  author={Per Eystein L\onning},
  journal={Endocrine-related cancer},
  volume={11 2},
The development of aromatase inhibitors for breast cancer therapy is a result of successful translational research exploring the biochemical effects of different compounds in vivo. Studies assessing plasma oestrogen levels as well as in vivo aromatase inhibition have revealed a consistent difference with respect to biochemical efficacy between the third generation compounds (anastrozole, letrozole and exemestane) and the previous, first and second generation drugs, corresponding to the improved… CONTINUE READING