Aromatase inhibitors as adjuvant treatment of breast cancer.

  title={Aromatase inhibitors as adjuvant treatment of breast cancer.},
  author={J{\"u}rgen Geisler and Per Eystein L\onning},
  journal={Critical reviews in oncology/hematology},
  volume={57 1},
The development of the novel, third-generation aromatase inhibitors and inactivators represents a major improvement of endocrine therapy in breast cancer. Subsequent to phase III studies revealing clinical superiority of these drugs compared to conventional therapy as second- and first-line treatment for advanced disease, several randomised studies have found these compounds, administered either as monotherapy or in sequence with tamoxifen, to improve relapse-free survival compared to tamoxifen… CONTINUE READING

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