Aromatase in the normal breast and breast cancer

@article{Brodie1997AromataseIT,
  title={Aromatase in the normal breast and breast cancer},
  author={Angela Brodie and Qing Lu and Junji Nakamura},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={1997},
  volume={61},
  pages={281-286}
}
Adipose tissue and muscle constitute the larger proportion of body mass, and therefore aromatization in these tissues is the major source of circulating estrogens in postmenopausal women. Although plasma estrogen concentrations are very low, levels in breast cancers from postmenopausal patients are reported to be 10-fold higher than in plasma and normal tissue. Whereas studies on aromatase activity in the tumor suggest that estrogen may be produced locally, the significance of this contribution… CONTINUE READING

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AN ANALYSIS OF ESTROGEN METABOLISM AND BREAST CANCER RISK

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