Aromatase in human endometrial carcinoma and hyperplasia. Immunohistochemical, in situ hybridization, and biochemical studies.

@article{Watanabe1995AromataseIH,
  title={Aromatase in human endometrial carcinoma and hyperplasia. Immunohistochemical, in situ hybridization, and biochemical studies.},
  author={Kazuo Watanabe and Hironobu Sasano and Nobuhiro Harada and Masanori Ozaki and Hitoshi Niikura and Shinya Sato and Akira Yajima},
  journal={The American journal of pathology},
  year={1995},
  volume={146 2},
  pages={491-500}
}
The expression of P450 aromatase and other steroidogenic enzymes were evaluated in 42 endometrioid endometrial carcinomas, 23 endometrial hyperplasias, and 7 normal endometrial specimens. These findings were correlated with clinicopathological findings to elucidate the possible biological significance of in situ estrogen production in the development of human endometrial carcinoma. Only weak aromatase immunoreactivity was observed in vascular walls and myometrial cells. In contrast, strong… CONTINUE READING

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