Aromatase-immunoreactivity is localised specifically in neurones in the developing mouse hypothalamus and cortex.

@article{Beyer1994AromataseimmunoreactivityIL,
  title={Aromatase-immunoreactivity is localised specifically in neurones in the developing mouse hypothalamus and cortex.},
  author={Cordian Beyer and Shawn J. Green and Patrick J. Barker and Neville S. Huskisson and John B. Hutchison},
  journal={Brain research},
  year={1994},
  volume={638 1-2},
  pages={203-10}
}
Local formation of oestrogens from androgens by aromatase cytochrome P-450 within brain cells is crucial for the sexual differentiation of the mammalian CNS. Aromatase activity has been detected in several brain regions of the developing rodent brain. In the present study, we used a mouse-specific, peptide-generated, polyclonal aromatase antibody to determine whether neurones and/or glial cells in the developing brain are involved in androgen aromatization and if aromatase-immunoreactive (Arom… CONTINUE READING

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