Aromatase expression in the ovary: hormonal and molecular regulation.

Abstract

Estrogens are synthesized by the aromatase enzyme encoded by the Cyp19a1 gene, which contains an unusually large regulatory region. In most mammals, aromatase expression is under the control of two distinct promoters a gonad- and a brain-specific promoter. In humans, this gene contains 10 tissue-specific promoters that are alternatively used in various cell… (More)
DOI: 10.1016/j.steroids.2008.01.017

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